This book constitutes the refereed proceedings of the 22nd International Conference on Services Computing – SCC 2025, Held as Part of the Services Conference Federation, SCF 2025, held in Hong Kong, China during September 27–30, 2025. The 7 full papers included in this book were carefully reviewed and selected from 11 submissions. The papers focus on the latest fundamental advances in the state of the art and practice of business modeling, business consulting, solution creation, service delivery, and software architecture design, development, and deployment.