This book constitutes the refereed proceedings of the 23rd International Conference on Product-Focused Software Process Improvement, PROFES 2022, which took place in Jyväskylä, Finland in November 2022. The 24 full technical papers, 9 short papers, and 6 poster papers presented in this volume were carefully reviewed and selected from 75 submissions. The book also contains and 8 doctoral symposium papers and 7 tutorial and workshop papers. The contributions were organized in topical sections as follows: Keynote; Cloud and AI; Empirical Studies; Process Management; Refactoring and Technical Dept; Software Business and Digital Innovation; Testing and Bug Prediction; Posters; Tutorials; Workshop on Engineering Processes and Practices for Quantum Software (PPQS’22); 1st Workshop on Computational Intelligence and Software Engineering (CISE 2022); Doctoral Symposium.