This book features a collection of high-quality, peer-reviewed papers presented at the Fifth International Conference on Intelligent Computing and Communication (ICICC 2021) organized by the Department of Computer Science and Engineering and Department of Computer Science and Technology, Dayananda Sagar University, Bengaluru, India, on November 26 - 27, 2021. The book is organized in two volumes and discusses advanced and multi-disciplinary research regarding the design of smart computing and informatics. It focuses on innovation paradigms in system knowledge, intelligence, and sustainability that can be applied to provide practical solutions to a number of problems in society, the environment and industry. Further, the book also addresses the deployment of emerging computational and knowledge transfer approaches, optimizing solutions in various disciplines of science, technology, and healthcare.