This book constitutes the refereed post proceedings of the 16th International Joint Conference on Knowledge Discovery, Knowledge Engineering and Knowledge Management, IC3K 2024, held in Porto, Portugal during November 17–19, 2024. The 12 full papers and 5 short papers included in this book were carefully reviewed and selected from 175 submissions. They were organized in topical sections as follows: knowledge discovery and information retrieval; knowledge engineering and ontology development and knowledge management and information systems.