This work marked the beginning of an era when the cure of malaria with antimalarial drugs became seriously menaced by the emergence of drug resistance on a global scale. The book embraces current knowledge of the nature of the parasites and the host responses, the development of drugs and drug resistance, techniques for the experimental and clinical investigations of drugs and the role of chemotherapy in the management of malaria. The references are extensive and an Addendum covers the period between the submission of the initial manuscript and its final printing.