This book LNCS 15336 constitutes the refereed proceedings of the 13th International Conference on Health Information Science, HIS 2024, held in Hong Kong, China, during December 8-10, 2024. The 18 full papers and 11 short papers were carefully reviewed and selected from 59 submissions. The scope of the conference includes: (1) medical/health/biomedicine information resources, such as patient medical records, devices and equipments, software and tools to capture, store, retrieve, process, analyze, and optimize the use of information in the health domain; (2) data management, data mining, and knowledge discovery, all of which play a key role in decision-making, management of public health, examination of standards, privacy and security issues; (3) computer visualization and artificial intelligence for computer-aided diagnosis; (4) development of new architectures and applications for health information systems.