This book constitutes the refereed proceedings of the 8th International Conference on Health Information Science, HIS 2019, held in Xi’an, China, in October 2019. The 14 full papers and 14 short papers presented were carefully reviewed and selected from 60 submissions. The papers are organized in topical sections named: Medical Information System and Platform; Mining Medical Data; EEG and ECG; Medical Image; Mental Health; and Healthcare.