This book constitutes the thoroughly refereed post-conference proceedings of the 6th International Conference on Mobile, Secure and Programmable Networking, held in Paris, France, in October 2020. The 16 full papers presented in this volume were carefully reviewed and selected from 31 submissions. They discuss new trends in networking infrastructures, security, services and applications while focusing on virtualization and cloud computing for networks, network programming, software defined networks (SDN) and their security.