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A Karger 'Publishing Highlights 1890-2015' title At the time of writing his clinical observations concerning Beriberi in Japan, Grimm was in tune with scientific ideas of the day when he postulated that the disease may be prevented by a change of diet even though he still saw it as an infection rather than the severe deficit of thiamine we know it to be. Studies such as these ultimately led to the detection of the vitamins and their role. (German publication)