This book constitutes the 4th International Conference on Artificial Intelligence and Knowledge Processing, AIKP 2024, held in Johannesburg Business School, Johannesburg, South Africa, during August 22–24, 2024. The 18 full papers included in this book were carefully reviewed and selected from 76 submissions. This AIKP 2024 topics covered in these proceedings; including machine learning; natural language processing; computer vision; robotics; data mining; quantum AI; and cognitive computing.