Author Description

<p>‘ENHANZE® drug delivery technology: Advancing subcutaneous drug delivery using recombinant human hyaluronidase PH20’ provides readers with in-depth information on the potential benefits and challenges of subcutaneous (SC) drug delivery, the biology of hyaluronan and hyaluronidases in the SC space, and a comprehensive overview on the history of hyaluronidases and the development of recombinant human hyaluronidase PH20 (rHuPH20). </p><p>Current applications of rHuPH20 as well as approved biotherapeutics utilizing HuPH20-facilitated SC drug delivery are summarized, and the underlying non-clinical and clinical development approaches are introduced as a basis for future application to biologics in various disease areas.</p><p><br></p><p>Table of Contents:</p><p><br></p><p>• Introduction to subcutaneous drug delivery</p><p>• Biology of hyaluronan and hyaluronidases in the subcutaneous space</p><p>• History of hyaluronidases and development of rHuPH20</p><p>• The ENHANZE® platform: Clinical applications of a subcutaneous drug delivery technology</p><p>• Application of ENHANZE® drug delivery technology: Development of currently marketed products</p>