This proceedings consists of selected papers presented at the International Conference on Computer Science and Technology (CST2016), which was successfully held in Shenzhen, China during January 8-10, 2016.CST2016 covered a wide range of fundamental studies, technical innovations and industrial applications in 7 areas, namely Computer Systems, Computer Network, Security, Databases and Information Systems, Artificial Intelligence and Multimedia, Theory and Software Engineering and Computer Applications.CST 2016 aims to provide a forum for researchers, engineers, and students in the area of computer science and technology. It features unique mixed various topics in computer science and technology including big data, system architecture, hardware and applications. CST 2016 attracted more than 300 submissions. Among them, only 142 papers were accepted in to the conference after a stringent peer review process.