This comprehensive reference details the significant advances and applications of metal-catalyzed cyclization reactions in modern organic synthesis. The work, divided into two volumes, covers a vast array of transformations crucial for synthesizing natural products and therapeutic agents, discussing their fundamental principles, current state, scope, limitations, and mechanisms with illustrative examples. Volume 1 focuses on intramolecular coupling reactions, allylations, and ring openings, while Volume 2 explores epoxidations, cycloadditions, radical cyclizations, and ring-closing metathesis, providing a thorough overview for researchers and practitioners.

This work is presented as a significant compilation of metal-catalyzed cyclization reactions, highlighting their importance in organic synthesis for natural product and therapeutic agent development. The text aims to provide a detailed overview of commonly used transformations, including their principles, scope, limitations, and mechanisms, supported by practical examples. The division into two volumes allows for a comprehensive exploration of distinct reaction types, from intramolecular couplings to cycloadditions and metathesis. The authors' intent is to serve as a valuable resource for chemists seeking to apply these advanced synthetic methodologies.