Author Description

Based on the proceedings of a conference held at Georgetown University. Provides expert guidance on assessing the clinical significance--whether transient and adaptive, or irreversible and pathological--of changes in the quality and quantity of sperm production after environmental chemical exposure. Presents EPA procedures and policies to estimate risk of injury to the male reproductive system, value of testicular and sperm profiles in optimizing reproductive success: lessons from selective breeding programs of domestic and laboratory animals, effects of radiation therapy and chemotherapy on testicular function, and calculation of incidence of infertility in human populations from sperm measures using the two-distribution model.