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Can taking misoprostol affect future pregnancy? The results of one study suggest that if a woman who has never given birth has an early medical abortion using Mifepristone and Misoprostol (or other protaglandine) it will not cause problems during a future wanted pregnancy. Can misoprostol abort 2 weeks pregnant? Twenty women who requested early first trimester termination of pregnancy were recruited to study the tolerability of a 2 week course of oral misoprostol after termination of pregnancy by mifepristone and vaginal misoprostol. Ten patients (50) complained of mild diarrhea during the 2 week course of misoprostol.