Jessica Drew must thwart the expansionist plans of media mogul Rupert Dockery, who seeks to control her. Dockery's machinations threaten not only Spider-Woman's autonomy but also the life of her best friend, forcing Jessica into an unlikely alliance with the Enforcer. The narrative escalates with the introduction of Werewolf by Night and the debut of the Hornet, before Chris Claremont takes the helm, bringing the X-Men into Jessica's orbit to confront the formidable Juggernaut. The story is told through a sequential art narrative, primarily in a third-person perspective.

This volume collects issues #26-38 of the 1978 Spider-Woman series, featuring storylines by Michael Fleisher and Chris Claremont. The collection highlights key character introductions and team-ups, including the debut of Hornet and the first appearances of Siryn and Werewolf by Night. The narrative arc culminates in a significant crossover with the X-Men, pitting Spider-Woman and the mutants against the powerful Juggernaut. This compilation offers a look at Spider-Woman's adventures during a period of significant creative input from prominent Marvel writers.