Archie's relationship with Betty is in jeopardy following a mysterious 'lipstick incident,' and he must navigate the complexities of teenage romance and friendship to mend it. The narrative focuses on the core group of Riverdale teens, with this issue highlighting the bond between Dilton and Moose. The story unfolds within the familiar, contemporary setting of Riverdale High, exploring themes of loyalty and reconciliation.

This issue of Archie (2015-) #4 continues the narrative momentum of the series, focusing on interpersonal relationships and character development. The introduction of guest artist Annie Wu is noted, suggesting a potential shift or enhancement in the visual storytelling. The plot points, such as the 'lipstick incident' and the spotlight on Dilton and Moose, indicate a focus on relatable teenage drama and the exploration of friendship dynamics. The series, in general, has been praised for its modern take on classic characters, and this issue likely contributes to that ongoing appeal by delving into the emotional complexities of its young protagonists.