This dissertation investigates the chemical and physical changes occurring within the organic matrix of dentin during the process of caries development. Authored by Gijs Kleter, this work draws upon research in organic chemistry and biomaterials science to analyze the degradation pathways and structural alterations of dentin's organic components under cariogenic conditions. The study aims to elucidate the mechanisms by which the organic matrix contributes to or resists the progression of dental caries, providing a deeper understanding of tissue demineralization and remineralization processes.

This work is a specialized academic dissertation likely intended for researchers and advanced students in dentistry, biomaterials, and organic chemistry. Its focus on the intricate details of dentin's organic matrix suggests a dense, technical read that contributes to a specific field of scientific inquiry. The publication format as a dissertation implies a rigorous, data-driven approach to understanding caries at a molecular level.