This monograph evaluates the carcinogenic risk to humans of tobacco smoke and involuntary smoking. The International Agency for Research on Cancer (IARC) Working Group convened to assess the available scientific evidence on the carcinogenicity of tobacco smoke, both active and passive. This volume synthesizes findings from epidemiological studies, animal bioassays, and mechanistic data to determine the classification of tobacco smoke and its components regarding human cancer. The evaluation considers the complex mixture of chemicals present in tobacco smoke and the various routes of exposure.

This publication is a critical assessment by the IARC, a leading international body for cancer research, providing authoritative classifications on carcinogens. The monograph's findings are foundational for public health policies and regulations worldwide aimed at reducing tobacco-related diseases. Its rigorous scientific review ensures that the conclusions are based on the totality of evidence, making it a key reference for researchers, policymakers, and health professionals. The work is expected to be a definitive statement on the carcinogenic hazards of tobacco smoke.