The life and mission of Marcus Whitman, a pivotal figure in the westward expansion of the United States, is examined through the lens of his challenging journey and ultimate sacrifice. Nard Jones utilizes contemporary letters, mission documents, and the diaries of pioneer women to chronicle the Whitmans' arduous trek west in 1836 and their establishment of a mission near present-day Walla Walla, Washington. The narrative explores the profound physical and mental hardships endured by these pioneers, alongside the growing resentment of the indigenous population, which culminated in the tragic massacre of the Whitmans and others at Waiilatpu in November 1847.

This historical account is presented as a sympathetic exploration of the Whitman mission and the challenges faced by pioneers during westward expansion. The narrative aims to balance the pioneers' struggles with the indigenous perspective, detailing the events leading up to the tragic massacre. The book's reliance on primary source materials like letters and diaries suggests a focus on authentic historical detail and personal experiences. The inclusion of photographs and an index further indicates a comprehensive approach to documenting this significant period in American history.