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What's scleroderma, as well as just how will it influence you? Scleroderma is an autoimmune illness by which regular cells is swapped out with thick, thick fibrous tissue. It's a persistent, albeit uncommon, situation. The body's immune system usually helps within the body 's safeguard against infection and sickness. The body's immune system of scleroderma individuals leads to some other cells to make far too much collagen (a protein).