The book investigates the nature and production of Latin manuscript books created before the year 1600. It draws upon the author's extensive scholarship in the field to examine the physical characteristics, contents, and cultural significance of these historical documents. The work aims to provide a comprehensive overview for scholars and enthusiasts interested in the transition from manuscript to print culture.

This work is recognized as a foundational text in the study of pre-1600 Latin manuscripts. Scholars appreciate Kristeller's meticulous research and comprehensive scope, which synthesizes a vast amount of material into an accessible format. The book is frequently cited in academic works on medieval and Renaissance book history, paleography, and codicology. It serves as an essential reference for understanding the material culture of books prior to the widespread adoption of printing.