A young girl named Deady navigates a macabre world filled with the undead and supernatural creatures. Deady, an orphaned girl with a penchant for the morbid, seeks to understand her place in a world where death is a constant companion. She is pursued by various entities, both living and spectral, who either wish to exploit her unique connection to the afterlife or simply see her as another soul to claim. The narrative unfolds through a series of darkly whimsical and often unsettling vignettes, exploring themes of mortality, innocence, and the grotesque.

The Book of Deady is recognized for its distinctive gothic aesthetic and its exploration of dark, whimsical themes. Readers often praise Aurelio Voltaire's unique artistic style, which imbues the macabre with a certain charm. The collection is noted for its blend of horror and dark humor, creating a narrative that is both unsettling and engaging. Its episodic nature allows for varied encounters with the supernatural, centering on the enigmatic character of Deady.