A group of teenagers on the run discovers their parents are supervillains and must learn to harness their own nascent powers to survive. The newly formed Runaways, a collection of disparate youths fleeing abusive or neglectful families, find themselves fugitives from the law and targets of their own parents, the Pride. Led by Nico Minoru, Chase Stein, Karolina Dean, Gertrude Yorkes, and Molly Hayes, they must navigate the treacherous landscape of New York City, relying on each other and their inherited abilities to uncover the truth about their parents' sinister agenda and forge their own destiny.

This volume of Runaways is celebrated for its compelling character dynamics and the unique premise of teenage superheroes rebelling against their supervillain parents. Readers often highlight the strong sense of found family that develops among the diverse cast of characters, each struggling with their newfound powers and their parents' dark secrets. The blend of action, humor, and genuine emotional depth resonates with audiences, making it a standout in the superhero genre. The narrative's exploration of identity and belonging, set against a backdrop of high-stakes adventure, has earned it a dedicated following.