The Exterminators face their ultimate challenge as a demonic cockroach deity and his monstrous insect army threaten to bring about humanity's end. The exterminators, a group dedicated to fighting supernatural threats, must confront A.J., a former partner of Henry's who has been reborn as a grotesque, redneck-inspired Egyptian god. Commanding an army of giant cockroaches filled with hatred for humanity, A.J. is on a mission to trigger insect Armageddon. With time running out, the survival of the human race hangs precariously in the balance.

The Exterminators concludes its run with a cataclysmic finale, pitting the titular heroes against a formidable, grotesque foe. The narrative escalates to a global threat, focusing on the potential extinction of humanity by an insectoid apocalypse. The series is noted for its cult following and its blend of horror and science fiction elements. This final installment promises a dramatic and intense resolution to the established conflicts.