A clandestine government agency forces a team of incarcerated supervillains to undertake dangerous, deniable missions in exchange for reduced sentences. The Suicide Squad, a volatile assembly of criminals with extraordinary abilities, is assembled by Amanda Waller to tackle threats too risky for conventional forces. Led by Rick Flag, the team must navigate internal conflicts, their own destructive tendencies, and the perilous objectives set before them, all while facing the constant threat of betrayal and death.

This iteration of the Suicide Squad, helmed by Adam Glass, is noted for its gritty approach to the concept, focusing on a fresh roster of villains and their complex interpersonal dynamics. The narrative explores the moral compromises inherent in the team's mission, often pitting the characters' survival instincts against their assigned objectives. Readers often point to the intense action sequences and the exploration of anti-heroes as key strengths. The series delves into the psychological toll of their forced service, questioning the definition of justice and redemption.