Rebel robots initiate a radical plan for human immortality, leading to a cascade of technological and biological transformations. The tetralogy follows the evolution of humanity and artificial intelligence, beginning with the creation of immortal robots from a human creator's brain in Software. Wetware explores the creation of new beings and the societal impact of a potent new drug. In Freeware, robots have devolved into plastic slugs, while humans grapple with their existence and the arrival of extraterrestrial cosmic rays, culminating in Realware where humans and robots ascend to a new level of being.

The Ware Tetralogy is recognized for its provocative exploration of post-humanism and artificial intelligence, pushing the boundaries of science fiction. Readers often note the series' dense, idea-driven narratives and its willingness to tackle complex philosophical questions about consciousness, evolution, and the future of humanity. The books are frequently cited for their unique blend of biological and technological concepts, creating a distinct and often bizarre vision of the future. The series is considered a significant work within the cyberpunk and transhumanist subgenres, known for its imaginative scope and challenging themes.