A stray kitten finds an unlikely home with a young couple and their two cats. Chis, a tiny calico kitten, is separated from her mother and siblings and must navigate the harsh realities of the outside world alone. Her life takes a turn when she encounters the kindhearted Hiroyama couple, who already have two cats, the aloof but gentle Tai and the energetic Shii. The narrative follows Chis's adjustment to her new environment, her interactions with her new feline siblings, and the humorous and heartwarming moments that arise from their cohabitation, all while exploring the challenges and joys of integrating a new pet into an established household.

The series is widely cherished for its gentle humor and authentic portrayal of feline behavior, earning it a dedicated following among cat lovers and manga readers alike. Readers often praise the series for its heartwarming moments and the endearing personalities of its characters, both human and feline. The slice-of-life narrative provides a comforting and relatable experience, capturing the simple joys and everyday occurrences of pet ownership. Its consistent charm and consistent quality have made it a beloved long-running series.