A group of super-powered teenagers discover they have been betrayed by their parents and must flee to survive. The newly formed Runaways, comprised of Nico Minado, Karolina Dean, Chase Stein, Gertrude Yorkes, and Molly Hayes, must learn to trust each other and harness their unique abilities to evade capture by the Pride, a sinister organization led by their own parents. Their objective is to expose the Pride's evil deeds and find a safe haven, all while navigating the complex dynamics of their found family and the dangers of a world that fears them.

This volume is celebrated for its fresh take on the superhero genre, introducing a compelling cast of young characters grappling with extraordinary circumstances and familial betrayal. The narrative skillfully balances action-packed sequences with the emotional turmoil of its protagonists, establishing a strong foundation for the series. Readers often highlight the dynamic character interactions and the unique premise that sets it apart from traditional superhero fare. The artwork is frequently praised for its vibrant style, effectively bringing the diverse cast and their powers to life.