A young man grapples with the mundane realities and existential anxieties of his life in a surreal, dreamlike landscape. The narrative follows Mome as he navigates a series of disconnected vignettes, encountering strange characters and unsettling situations that blur the lines between reality and imagination. He seeks meaning and connection in a world that often feels indifferent or hostile, constrained by the illogical rules of his environment and his own internal struggles.

Mome is recognized for its unique and often unsettling blend of the surreal and the mundane, a hallmark of Dash Shaw's distinctive artistic and narrative voice. Critics have noted the graphic novel's ability to evoke a sense of dreamlike disorientation, using its visual language to explore complex psychological themes. The work is often discussed in terms of its exploration of alienation and the search for connection in contemporary society. While its abstract nature can be challenging, readers often find the book to be a thought-provoking and visually arresting experience that lingers long after reading.