A black-ops mutant team is resurrected for a mission that will shatter their world. Wolverine, Psylocke, Archangel, and Fantomex are brought back from the dead by Cyclops to form a new X-Force, tasked with eliminating threats to mutantkind before they can escalate. However, this new team is plagued by internal conflict and the ghosts of their past, all while facing an enemy that seeks to unravel the very fabric of mutant existence.

Rick Remender's Uncanny X-Force is widely celebrated for its mature themes and gritty, character-driven narrative. Critics and readers alike praise its willingness to explore the moral complexities of superhero actions, particularly the concept of pre-emptive elimination of threats. The series is noted for its compelling character arcs, especially Wolverine's struggle with his past and leadership, and the introduction of formidable, morally ambiguous villains. The art style is often commended for its dynamic action and atmospheric tone, contributing to the book's dark and intense feel. This run is frequently cited as a high point for the X-Force title, offering a fresh and impactful take on the mutant black-ops team.