A mercenary with a mouth and a mutant with a mission collide in a chaotic quest for a mystical artifact. Deadpool, the wisecracking assassin, finds himself reluctantly allied with Cable, the grizzled soldier from the future, as they race against time and a host of dangerous adversaries to secure the Hand of Cygnus. Their opposing personalities and methods create constant friction, but the fate of reality hinges on their ability to overcome their differences and the formidable forces seeking the artifact for their own nefarious purposes.

This collection is celebrated by fans for its definitive portrayal of the early Deadpool and Cable team-ups, highlighting the perfect synergy between brutal action and sharp wit. The dynamic between the two characters is frequently cited as a major draw, with their contrasting personalities providing ample comedic and dramatic tension. Readers appreciate the comprehensive nature of the 'Ultimate Collection' format, which gathers significant story arcs in one volume. The blend of Zircher's dynamic art and the sharp writing captures the essence of these beloved Marvel anti-heroes.