A desperate search for a cure plunges Kaiman and Nikaido deeper into the treacherous world of Hole and the sorcerers who inhabit it. Kaiman, a reptilian-headed man with amnesia, believes he was cursed by a sorcerer and seeks to find the one responsible to reverse the transformation. He and his loyal friend Nikaido navigate the violent and chaotic city of Hole, a place where sorcerers experiment on humans and where death is a common occurrence. Their quest is fraught with danger as they face off against powerful sorcerers, including the enigmatic En and his associates, who are also hunting for Kaiman and the truth behind his condition.

The Dorohedoro series, and Volume 2 specifically, is celebrated for its unique blend of dark fantasy, visceral action, and absurdist humor. Readers often praise Q Hayashida's distinctive art style, which masterfully balances grotesque imagery with moments of surprising charm. The intricate world-building of Hole and the sorcerer's society, coupled with complex character dynamics, draws readers into its chaotic narrative. While the plot can be dense and the violence graphic, the series is lauded for its originality and its ability to keep readers engaged with its unpredictable twists and turns.