MHC2: A Practical Approach offers a comprehensive and accessible guide to the fast-growing and fascinating field of MHC research. This companion volume to MHC1 covers topics including: generation of HLA-specific human monoclonal antibodies; sequencing of proteins; assembly of MHC molecules; expression, purification, and characterization of recombinant soluble MHC class I molecules; mapping the human MHC; derivation and analysis of MHC transgenic mice; cell-surface MHC antigen imaging; sequence analysis of MHC molecules; and techniques to identify the rules governing class II MHC-peptide interaction. This informative guide will be an invaluable aid to clinicians, researchers, and graduate students in the field of immunology.