A new Multiverse is born, and with it, the origins of Earth-3's most malevolent villains are revealed. Spinning out of the events of Dark Nights: Death Metal, the Crime Syndicate—Ultraman, Superia, Johnny Quick, Atomica, and Emerald Knight—are united by a common foe. However, their fragile alliance is tested as they face their greatest threat yet, the biggest Starro of them all, while simultaneously battling their own internal conflicts and ambitions.

The Crime Syndicate series is noted for delving into the origins of DC's dark mirror of the Justice League, exploring their motivations and the volatile nature of their alliances. The narrative focuses on the internal dynamics and external threats faced by these villains as they navigate a newly formed Multiverse. The collected edition provides a complete arc, showcasing the team's first major challenge and the seeds of future conflicts. This story is positioned as a significant event following the major crossover of Dark Nights: Death Metal.