This book investigates the physiological and clinical implications of beta-adrenergic blockade, a critical area in cardiovascular medicine. Authored by Eugene Braunwald MD, a renowned figure in cardiology, the work draws upon extensive research and clinical experience to elucidate the mechanisms and applications of these drugs. It presents a comprehensive overview of beta-blockers, detailing their effects on the heart and vasculature, and their therapeutic roles in managing conditions such as hypertension, angina, and arrhythmias.

As a publication from 1978 authored by Eugene Braunwald, this work represents a foundational text in the understanding of beta-adrenergic blockade during that era. Its content likely reflects the state of knowledge and clinical practice at the time of its publication, offering historical context for the development of cardiovascular therapeutics. The book is expected to be a technical resource for medical professionals and researchers interested in the early scientific and clinical perspectives on beta-blocker therapy.