The Shoe must go on chronicles the daily absurdities and political satire emanating from the Treetops swamp, where the inhabitants navigate a world defined by bureaucratic incompetence and social folly.

Shoe, the central character, operates as a cynical editor managing a staff of eccentric birds and animals who struggle to maintain a semblance of order in their newsroom. The narrative framework relies on the classic daily comic strip format, utilizing short, punchy exchanges to highlight the logical inconsistencies of the characters' environment. Each strip functions as a self-contained observation on human behavior, filtered through the lens of anthropomorphic wildlife. The primary conflict stems from the characters' attempts to reconcile their personal ambitions with the chaotic, often nonsensical demands of their professional and social lives.

Readers frequently highlight the sharp wit and observational humor that defined Jeff MacNelly's work throughout his career. Discussion often centers on the effectiveness of the strip's political satire, which managed to remain biting without losing its accessibility to a general audience. Critics often point to the expressive quality of the artwork, noting how the visual style complements the cynical tone of the writing. The balance between character-driven humor and broader social commentary is frequently cited as a primary reason for the strip's longevity. Many fans appreciate the way the series captures the mundane frustrations of office life while maintaining a distinct, whimsical atmosphere.