This report investigates the classification and regulation of Carcinogenic, Mutagenic, or Reprotoxic (CMR) substances within the European Union. The report aims to assess the extent to which registrants and notifiers adhere to the harmonised classification for CMR substances as listed in Annex VI of the CLP Regulation. It also seeks to identify substances that are classified for CMR properties by some entities but currently lack a harmonised classification, highlighting potential gaps in regulatory alignment.

This report serves as a technical assessment for regulatory bodies and industry stakeholders involved in chemical safety within the European Union. Its focus is on the practical application of classification rules for hazardous substances, providing data to inform compliance efforts and regulatory updates. The analysis is expected to be of interest to those working in chemical registration, risk assessment, and regulatory affairs, offering insights into the current state of CMR substance classification and potential areas for further regulatory attention.