Atomic-bred monsters emerge from the Utah desert, forcing Professor Bruttenholm and a young Hellboy into a dangerous investigation. The origin of these creatures appears to be a mysterious glass element discovered in the desert, which is opening a portal to our world. Bruttenholm, along with an agent possessed by vampires, must uncover the truth behind this element and stop the monstrous incursions before more civilians are killed. The narrative follows the events of a five-issue miniseries, setting the stage for future B.P.R.D. stories.

This comic miniseries is noted for its collaboration between Mike Mignola and John Arcudi, bringing together elements of science fiction, horror, and supernatural mystery. The inclusion of a young Hellboy and the connection to other B.P.R.D. narratives suggest a story that expands the established lore of the universe. The premise of atomic-bred monsters and a mysterious glass element points to a narrative that blends classic monster-movie tropes with Mignola's signature dark fantasy aesthetic. The collected edition serves as a self-contained story while also acting as a bridge to further adventures within the B.P.R.D. continuity.