After returning from an intergalactic excursion to find Earth completely deserted, the Planet Express crew must navigate a chaotic temporal crisis to locate their missing colleagues and the planet's vanished population. Fry, Leela, Bender, and Cubert face a series of escalating threats, beginning with hostile alien invaders and spiraling into a complex struggle against the mechanics of time itself. The narrative follows the crew as they attempt to restore normalcy, moving through various eras and dimensions while dealing with the consequences of their own interference. The story is presented through a fast-paced, episodic graphic novel format that emphasizes visual gags and rapid-fire dialogue.

This collection is received as a faithful expansion of the source material, capturing the specific comedic tone and irreverent spirit of the animated series. Readers often highlight the clever utilization of the time travel premise to facilitate absurd scenarios that would be difficult to execute in other formats. The pacing is noted for its relentless energy, mirroring the frantic nature of the television show's writing style. The work is generally regarded as a successful translation of the medium, providing fans with a substantial narrative that maintains the established character voices and humor.