This volume investigates the fundamental biological, psychological, and social mechanisms that constitute drug dependence. The authors, Griffith Edwards and Malcolm H. Lader, utilize a multidisciplinary framework to synthesize clinical research and theoretical models. By examining the intersection of pharmacology and behavioral science, the text provides a comprehensive overview of the factors contributing to substance abuse and the challenges inherent in its treatment.

Experts recognize this monograph as a foundational text for understanding the complexity of addiction through a multidisciplinary lens. Readers frequently note the academic density of the prose, which is intended for clinicians and researchers in the field of substance abuse.