This volume investigates the physiological and chemical mechanisms underlying pain perception and the pharmacological interventions available for its management as understood in the early 1960s. The text compiles research presented by international experts at the First International Pharmacological Meeting, providing a snapshot of the scientific consensus and experimental methodologies prevalent during that era of medical development.

Experts view this text as a historical record of the foundational discussions that shaped mid-20th-century pain research. Readers frequently note the academic density of the prose and its utility as a primary source for understanding the evolution of pharmacological science.