The book explores the enduring spirit and resilience of Indigenous peoples in the face of historical injustices and contemporary challenges. Rez Cheese 2 builds upon the themes introduced in its predecessor, focusing on the concept of not giving up despite immense hardship. It highlights inspirational figures from Indigenous heritage across the Americas, contrasting their strength and cultural values with destructive forces such as suicide, drug addiction, sex trafficking, and pornography addiction, which are presented as antithetical to Indigenous ways of life and detrimental to the soul.

The book's premise suggests a powerful and potentially challenging examination of social issues within Indigenous communities. By focusing on resilience and inspirational figures, it aims to offer a counter-narrative to prevalent negative stereotypes and societal problems. The inclusion of specific issues like addiction and trafficking indicates a direct engagement with difficult realities, framed within a context of cultural strength and historical context.