This volume presents cutting-edge research in bioinformatics and its applications, stemming from the 15th International Symposium on Bioinformatics Research and Applications (ISBRA 2019). The proceedings feature 22 carefully selected full papers, chosen from 95 submissions, reflecting a rigorous review process. These papers cover a diverse range of topics within the field, including advanced genome analysis, intricate systems biology, sophisticated computational proteomics, and the application of machine and deep learning techniques. The collection also addresses crucial aspects of data analysis and methodology, offering insights into the latest advancements and challenges in bioinformatics.

This collection of papers from ISBRA 2019 offers a snapshot of current research in bioinformatics, focusing on computational and data-driven approaches to biological problems. The selection process, involving 22 papers from 95 submissions, suggests a high standard for the included work. The thematic organization into genome analysis, systems biology, computational proteomics, machine learning, and data analysis indicates a broad yet focused scope, appealing to researchers and practitioners in these specialized areas.