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Protein misfolding and aggregation are hallmarks of several neurodegenerative proteinopathies. Though multiple factors like aging, oxidative stress, mitochondrial dysfunction, proteotoxic insults, genetic inconsistency, etc. are responsible for the dysfunction of the neuronal protein quality control system, targeting protein quality control has become an auspicious approach to halt the propagation of neurodegeneration. Quality Control of Cellular Protein in Neurodegenerative Disorders provides diverse aspects exploring the role of the protein quality control in neurodegenerative disorders and potential therapeutic strategies to combat the development and propagation of neurodegeneration. Featuring coverage on a broad range of topics such as molecular chaperones, protein misfolding, and stress signaling, this book is ideally designed for neurobiologists, neuropsychologists, neurophysiologists, medical professionals, neuropathologists, researchers, academicians, students, and practitioners engaged in studies of the protein quality control system in neuronal cells.
This book investigates the critical role of the cellular protein quality control system in the development and progression of neurodegenerative disorders. It explores how factors such as aging, oxidative stress, and genetic inconsistencies can impair this system, leading to protein misfolding and aggregation, which are hallmarks of diseases like Alzheimer's and Parkinson's. The text examines potential therapeutic strategies that target protein quality control mechanisms as a means to halt neurodegeneration, drawing on research in molecular chaperones, stress signaling, and proteotoxicity.
This book is designed for specialists in neurobiology, neuropsychology, and neuropathology, offering a comprehensive overview of protein quality control in neurodegenerative disorders. It synthesizes diverse research on molecular chaperones, protein misfolding, and stress signaling, presenting potential therapeutic avenues. The text is intended for researchers, academicians, students, and practitioners actively engaged in the study of neuronal protein quality control.
Page Count:
515
Publication Date:
2020-02-14
Publisher:
IGI Global
ISBN-10:
1799813185
ISBN-13:
9781799813187
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