A cyber-physical system (CPS) is a system featuring a tight combination of, and coordination between, the system’s computational and physical elements. This book serves as a one-stop reference on nearly all aspects of CPS, including concepts, architectures, techniques, protocols, standards, algorithms, recent progress, and system implementations. In addition to describing the design and implementation of CPS architecture, it covers many of the new and emerging application scenarios such as the connected healthcare for long-term chronicle disease monitoring and family care.