A synchronized phone call from the Rossum Corporation unleashes a mind-wiping plague, turning ordinary people into killers and plunging the world into a sudden apocalypse. Those who were not affected, including the Dollhouse's most capable actives like Echo and Alpha, must now navigate a world where Rossum's technological reach is vast and their own minds may be the next target. They must fight for survival against a relentless enemy and uncover the truth behind the global catastrophe, all while grappling with the potential for their own memories and identities to be erased.

This collected miniseries, building on the established universe of Joss Whedon's Dollhouse, continues the narrative with a focus on survival in a world plunged into chaos by Rossum Corporation's technology. The story is driven by the efforts of unaffected characters, including fan favorites Echo and Alpha, to navigate an apocalypse where mind control and technological manipulation are rampant. The writing, by series writers Andrew Chambliss, Maurissa Tancharoen, and Jed Whedon, aims to expand the lore and deliver action-packed scenarios. The comic continuation is designed to appeal to fans of the original show, offering a new chapter in the ongoing struggle against Rossum's pervasive influence and the threat to individual identity.