This volume investigates the physiological mechanisms of calcium antagonists and their potential for targeted therapeutic application across diverse tissue types. George B. Weiss, a recognized authority in pharmacology, synthesizes cellular and molecular research to explain how calcium mobilization varies within the heart, smooth muscle, and secretory systems. By establishing these biological distinctions, the text provides a framework for the development of specialized pharmacological agents with improved clinical efficacy.

Experts identify this work as a foundational reference for understanding the early development and physiological basis of calcium channel blockers. Readers frequently note the technical density of the prose, which is tailored specifically for clinicians and research scientists.