This work investigates the nature and progression of pernicious anemia, specifically focusing on cases identified as idiopathic of Addison. The author, William E. Gardner, presents a detailed examination of this severe blood disorder, which was poorly understood in the late 19th century. The text likely draws upon clinical observations and case studies available at the time to describe the symptoms, pathological changes, and potential outcomes associated with the condition. It aims to contribute to the medical understanding of this debilitating disease.

This historical medical text offers a specific window into the understanding of pernicious anemia at the time of its publication. The focus on 'idiopathic of Addison' suggests a detailed clinical case study approach, likely of interest to historians of medicine or hematologists studying the evolution of disease understanding. The work provides primary source material for understanding medical knowledge and practice in the late 19th century regarding blood disorders.