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Radicals--short lived, reactive molecules--are thought to play a major role in many oxidative processes within cells and to have implications in several human diseases, carcinogenesis, and aging. This unique and comprehensive volume brings together up-to-date information on the oxidation of amino acids, peptides, and proteins by free radicals and discusses the roles of such processes in biological systems. Topics include: the chemistry of amino acid and protein oxidation; the biochemical consequences of these reactions; the role of protein oxidation in normal physiology; the potential importance of protein oxidation in human health, including aging, heart disease, cancer, inflammation, and neurodegenerative diseases; and the possible prevention of disease processes by antioxidants and other protective strategies. Drawing on the latest research across a range of disciplines, this book will be important reading for researchers and graduate and postdoctoral students in the fields of radical biochemistry, physiology, and pathology.
This volume investigates the fundamental chemical mechanisms of radical-mediated protein oxidation and their subsequent impact on human health and disease pathology. Authors Michael J. Davies and Roger T. Dean synthesize extensive biochemical research to bridge the gap between molecular-level radical reactions and systemic physiological outcomes. The text provides a rigorous framework for understanding how oxidative damage to amino acids and proteins contributes to aging, carcinogenesis, and various chronic conditions.
What You Will Find
Experts recognize this work as a foundational text for researchers and graduate students specializing in radical biochemistry and oxidative stress. Readers frequently note the technical density of the prose, which serves as a comprehensive reference for those studying the intersection of chemistry and clinical pathology.
Page Count:
456
Publication Date:
1998-01-08
Publisher:
Oxford University Press
ISBN-10:
0198500971
ISBN-13:
9780198500971
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